While Rey Mysterio and fellow WWE Hall of Famer Booker T spent considerable time in WCW together, it was only when they were in WWE that their rivalry began. Known as King Booker, Booker T managed to take the World Championship from Mysterio in 2006.

During the dying days of WCW, Rey Mysterio Jr. and his group The Filthy Animalz often battled with a faction led by WWE Hall of Famer Jeff Jarrett. Decades later, Jarrett would defeat Mysterio to capture the AAA Mega Championship in 2018.

As Rey Mysterio Jr., Rey battled most of the top cruiserweights of the era in WCW, and that included up-and-comer Prince Iaukea. The two battled over Iaukea's World Television Championship, including a match at WCW SuperBrawl VIII.

During Spike Dudley's often-forgotten heel run in 2004, he immediately targeted WWE Cruiserweight Champion Rey Mysterio. During a match on SmackDown, Mysterio lost the title to Spike, thanks to interference from his Dudley Boyz brothers.

In 2010, Jack Swagger (a/k/a Jake Hager) was World Heavyweight Champion after cashing in his Money In The Bank briefcase. After a series of matches involving Rey Mysterio, Mysterio captured the title at the Fatal 4-Way PPV.

While also competing as Johnny Nitro, and Johnny Mundo, John Morrison battled against Rey Mysterio for the better part of a decade through WWE, AAA and Lucha Underground. Famously, the two had a modern classic on SmackDown in 2009.

One of Rey Mysterio's career lows was when he lost his mask in 1999 during a WCW match involving WWE Hall of Famer Kevin Nash. Mysterio got his revenge on Nash the following month, pinning him cleanly on an episode of WCW Nitro.

Rey Mysterio and Samoa Joe had a vicious feud in 2019 over the United States Championship. Mysterio failed to unseat The Samoan Submission Machine at Fastlane and WrestleMania XXXV, but did win the U.S. Title at Money In The Bank.

Rey Mysterio has found himself opposing The Usos (Jimmy and Jey Uso) many times over the years. Notably, Rey and son Dominik faced The Usos at both Money In The Bank and SummerSlam in 2021. Mysterio also teamed with Santos Escobar against the twins.

EXCUSE ME? Vickie Guerrero was once a trusted ally of Rey Mysterio's, particularly when fought for the honor of her late husband in Eddie in 2006. Soon after, however, Guerrero sided with her nephew Chavo and other heels in their battles against Rey. 

When Finn Balor joined The Judgment Day in 2022 and immediately kicked Edge out of the group, Rey and Dominik Mysterio were there to even the odds for Edge. Mysterio and Balor have since had several singles and tag team matches.

While Rey Mysterio has crossed paths with every member of The Judgment Day, Rhea Ripley is one that frequently given him a tough time. In addition to interfering in his matches, Ripley has constantly been in the ear of his son Dominik Mysterio.

Much like Kidman, WWE Hall of Famer Edge is better known as a tag team partner of Rey Mysterio than an opponent. Still, the two feuded in 2008 and 2009 on SmackDown, and briefly in 2022 when Edge formed The Judgment Day.

Rey Mysterio and Cody Rhodes had a rivalry in 2011 when Mysterio kneed Rhodes in the face with a knee brace, prompting Rhodes to wear a protective mask. This led to a match between them at WrestleMania XXVII.

Because of their similar cruiserweight styles, Rey Misterio Jr. and Ultimo Dragon were often matched against each other in WCW. This was capped off by the opening match at WCW Spring Stampede in 1997, where Misterio won.

MVP (Montel Vontavious Porter) wasn't the first person to underestimate Rey Mysterio. But at Armageddon in 2007, MVP intentionally counted himself out to avoid losing his U.S. Championship against Mysterio. They resumed their rivalry in 2019, when MVP returned to WWE.

The rivalry between Mysterio and Roman Reigns dates back to 2013, when The Shield battled Mysterio and The Usos. Things took a more violent turn when Reigns went after Dominik Mysterio, leading to a Hell In A Cell match against Rey in June of 2021.

While Rey Mysterio battled Brock Lesnar a few times over the years, their primary rivarly took place in 2019, after Lesnar destroyed Rey's son Dominik Mysterio. This led to a No Holds Barred Match with Lesnar at Survivor Series. Mysterio lost, despite a valiant effort.

In 2003, Rey Mysterio pursued Matt Hardy for his WWE Cruiserweight Championship. Whenever Mysterio got close, Hardy had his Mattitude Followers interfere. Mysterio finally had his chance for revenge at WrestleMania XIX, yet couldn't get the job done.

Throughout the years, Rey Mysterio and Psychosis have done battled numerous times, including a series of matches in AAA, Japan's WAR promotion, WCW and even once in WWE. Famously, the two competed at WCW's 1996 Bash at the Beach.

According to Cage Match, Rey Mysterio and Juventud Guerrera have done battle nearly 50 times (and likely far more) over the years. The two luchadors took their rivalry from AAA to ECW and from WCW to other promotions over the years.

While Rey Mysterio and Konnan have usually been portrayed as best friends (including Konnan inducting Mysterio into the WWE Hall of Fame), they feuded in 1997, when Konnan was part of the nWo, including a Mexican Death Match.

Rey Mysterio has feuded with WWE Hall of Famer Kane more than once over the years. In 2008, their bad blood led to a No Holds Barred Match at Cyber Sunday. A couple of years later, they feuded over the World Heavyweight Championship.

While Chris Jericho and Rey Mysterio faced one another in WCW, their primary rivalry took place in WWE circa 2009. Jericho attempted to unmask Mysterio, which led to an Intercontinental Title vs. Mask Match at The Bash PPV, which Mysterio triumphed in.

Randy Orton and Rey Mysterio have had several matches against each other over the years, but things became incredibly personal in 2006 when Orton implied Mysterio's late friend Eddie Guerrero was in hell. The two faced off at several PPVs that year, including WrestleMania XXII.

Early on in his WWE career, Rey Mysterio frequently clashed with Tajiri, including a feud over the WWE Cruiserweight Championship in 2003/2004. Interestingly, the two high-flyers also teamed up while both were part of the SmackDown roster.

Another faction that Rey Mysterio Jr. and The Filthy Animalz battled in WCW were The West Texas Rednecks, a group headed by the rap-hating Curt Hennig. Mysterio even teamed with Brad Armstrong of The No Limit Soldiers to get his hands on The Rednecks in 1999.

A mismatch on paper (and even in reality), Rey Mysterio always had to be on his A-game whenever he faced WWE Hall of Famer Mark Henry. Legitimately weighing double Mysterio's weight, Henry often gave Mysterio a challenge.

Veterans Rey Mysterio and Dolph Ziggler have been facing each other since SummerSlam in 2009, when they opened the show in an Intercontinental Title Match. More recently, the two had a series of tag team matches against one another in 2021/2022.

When Santos Escobar turned face in 2023, he was welcomed warmly by Rey Mysterio, bringing him and Legado Del Fantasma into the re-formed Latino World Order. Towards the end of the year, Escobar turned on Mysterio and the LWO.

The Natural Born Thrillers were a group of Power Plant rookies that replaced Rey Mysterio's Filthy Animalz as Eric Bischoff and Vince Russo's securty force in 2000. This led to a feud between the factions, including a match at WCW Fall Brawl.

Rey Mysterio made his WWE pay-per-view debut against WWE Hall of Famer Kurt Angle in 2002. The two men would go on to have several big matches over the years, including being two-thirds of a World Heavyweight Championship Match at WrestleMania XXII.

Rey Mysterio and Chris Benoit began facing off against one another in WCW, mostly in tag team matches. They took their feud to WWE in 2002, where both were members of opposite teams (Benoit with Kurt Angle and Mysterio with Edge) in the famed SmackDown Six. 

During their respective runs on the SmackDown roster, Rey Mysterio often found himself on the opposing end of Finlay. Mysterio battled The Man Who Likes To Fight at both No Mercy and Cyber Sunday in 2007, the latter of which was in a Stretcher Match.

The odds were already against Rey Mysterio when he captured the World Heavyweight Title in 2006, and became even moreso when he had to take on the massive Great Khali. Mysterio was pinned clean by Khali in a non-title match on SmackDown in one of their encounters.

Much like Finn Balor, Damian Priest has been a constant thorn in Rey Mysterio's side through The Judgment Day. In addition to tag team matches with other members of the group, Priest and Mysterio have met one-on-one many times.

While Rey Mysterio was better known for teaming with Billy Kidman (both in WCW and briefly in WWE), the two had a series of matches over the WCW Cruiserweight Championship in the late 1990s.

While Rey Mysterio and The Miz met a handful of times in the late 2000s (mosty in tag team matches), years later the two were often pitted against each other, including the finals of a 2011 tournament to crown a new WWE Champion. 

Between 2018 and 2020, Andrade was one of Rey Mysterio's most frequent opponents on SmackDown. This included a fantastic Two out of Three Falls Match, which was spoiled by the interference of Samoa Joe.

Rey Mysterio was Alberto Del Rio's first opponent when he joined WWE in 2010. The two had several matches on SmackDown, as well as later on in AAA and even on a WhatCulture Pro Wrestling show in 2017.

Talk about a mismatch: whenever Rey Mysterio met The Big Show, he always at a massive disadvantage in size. Following their brutal match at Backlash in 2003, Big Show picked up Mysterio (who was on a stretcher at the time) and slammed him into the ring post!

Rey Mysterio battled WWE Hall of Famer John Bradshaw Layfield numerous times in the mid-to-late 2000s, usually with JBL getting the victory. However, Mysterio pinned JBL in 21 seconds to win the Intercontinental Title at WrestleMania XXV, prompting JBL to announce his retirement.

When CM Punk formed his faction The Straight Edge Society in 2010, he targeted Rey Mysterio by insulting Rey's family. This led to a match at Over The Limit, in which Mysterio shaved The Straight Edge Superstar bald as per a pre-match stipulation.

When the nWo was created in 1996, Rey Misterio Jr. was a cruiserweight contender who stood up for the ideals of WCW. He was constantly ambushed by the nWo because of this, including a famous moment where Kevin Nash used his head as a lawn dart against a backstage trailer.

Although Rey Mysterio and Seth Rollins faced off a few times over the years, their primary feud was in 2020 when Rollins targeted the eye of Mysterio. This led to an Eye For An Eye Match at Extreme Rules, in which Rollins (allegedly) removed Mysterio's eyeball.

Throughout 1996, Rey Misterio Jr. and Dean Malenko were frequent rivals, battling over the WCW Cruiserweight Championship. This included bouts at Clash of the Champions, Hallowe'en Havoc and The Great American Bash.

Between 1996 and 2018, Rey Mysterio and Chavo Guerrero were often in opposite corners from each other. This includes a Cruiserweight Title match at 2001's WCW SuperBrawl Revenge, and a feud in lengthy WWE feud in 2006.

Rey Mysterio had a one-of-a-kind rivalry with his son Dominik Mysterio, which began in late 2022 and cultimated in a match at  WrestleMania XXIX. Since then, Dominik has been a constant thorn in his father's side, even crashing family events with his Judgment Day brethren.

Following the Chris Jericho feud, Rey Mysterio had another classic rivalry with his longtime friend Batista. Following the WWE Bragging Rights pay-per-view, Batista turned on Mysterio by saying "I'm gonna rip your head off!" leading to a brutal match at that year's Survivor Series.

While Rey Mysterio and his fellow WWE Hall of Famer Eddie Guerrero were often paired as best friends, they also feuded many times in their career. In WCW, they had a Title vs. Mask Match at Hallowen Havoc 1997. In WWE, their championship tag team run fell apart in early 2005, leading to a six-month feud that including them battling over the custody of Rey's own son Dominik.